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Richard A Yost is an American scientist. He is a Professor and Head of Analytical Chemistry at the University of Florida. He received his BS degree in Chemistry in 1974 from the University of Arizona, having performed undergraduate research in chromatography with Professor Mike Burke and his PhD degree in Analytical Chemistry in 1979 from Michigan State University, having performed graduate research with Professor Chris Enke. He then joined the faculty of the University of Florida.
He is the director of the Southeast Center for Integrated Metabolomics (SECIM) and of NIH's Metabolomics Consortium Coordinating Center (M3C). He is also a Professor of Pathology at both the University of Florida and the University of Utah/ARUP.
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome (SIDS) with no cure. To reveal the disease etiology, we generated stem cell-derived cardiomyocytes from HADHA-deficient hiPSCs and accelerated their maturation via a novel, engineered MicroRNA Maturation Cocktail (MiMaC) that upregulated the epigenetic regulator, HOPX.
This study reveals that TFPa/HADHA, a MLCL-AT-like enzyme, is required for FAO and cardiolipin remodeling, essential for functional mitochondria in human cardiomyocytes.
Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by unknown mechanisms. We report here a large metabolomics study of plasma and cerebrospinal fluid showing that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively.