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Rick Yost
Rick Yost
Person Spotlight

Richard A Yost is an American scientist. He is a Professor and Head of Analytical Chemistry at the University of Florida. He received his BS degree in Chemistry in 1974 from the University of Arizona, having performed undergraduate research in chromatography with Professor Mike Burke and his PhD degree in Analytical Chemistry in 1979 from Michigan State University, having performed graduate research with Professor Chris Enke. He then joined the faculty of the University of Florida.

He is the director of the Southeast Center for Integrated Metabolomics (SECIM) and of NIH's Metabolomics Consortium Coordinating Center (M3C). He is also a Professor of Pathology at both the University of Florida and the University of Utah/ARUP.

Megan Showalter
Megan Showalter
Study Spotlight

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes (part-I)

Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome (SIDS) with no cure. To reveal the disease etiology, we generated stem cell-derived cardiomyocytes from HADHA-deficient hiPSCs and accelerated their maturation via a novel, engineered MicroRNA Maturation Cocktail (MiMaC) that upregulated the epigenetic regulator, HOPX.

This study reveals that TFPa/HADHA, a MLCL-AT-like enzyme, is required for FAO and cardiolipin remodeling, essential for functional mitochondria in human cardiomyocytes.

Rachel Culp-Hill
Rachel Culp-Hill
Project Spotlight

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by unknown mechanisms. We report here a large metabolomics study of plasma and cerebrospinal fluid showing that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively.

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Grant 1U2CDK119889-01 of the NIH Common Fund Metabolomics Program.